Biography
Robert Carlisle is an Associate Professor in Biomedical Engineering. After completing a BSc in Biochemistry, an MSc in Toxicology and a Ph.D in Gene Delivery at Birmingham University, he worked for 8 years within the Department of Clinical Pharmacology and the Department of Oncology at the University of Oxford. In 2012 he became a member of the Engineering Science Faculty.
The majority of Bob’s work has been concerned with achieving systemic delivery of anti-cancer agents for the treatment of metastatic cancer. This has included the development and testing of novel nano-scale non-viral and viral gene delivery systems and liposomal agents for the delivery of conventional chemotherapeutics.
Research within his labs covers the full scope of therapeutic design, formulation and testing with emphasis on how the specificity and efficacy of therapy can be improved. He is the Director of the MSc in Nanotechnology for Medicine and Healthcare and was Associate Director of the Synthetic Biology CDT (2015-2022).
Key Papers
Professor Carlisle is the recipient of the CRS Jorge Heller JCR Outstanding Paper Award 2016, for his paper Increasing the Density of Nanomedicines Improves Their Ultrasound-mediated Delivery to Tumours.
He is also one of the authors of the 2018 paper Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial This detailed the results of a milestone study into the safety and feasibility of ultrasound devices used to enhance the delivery and distribution of anticancer drugs.
Most Recent Publications
The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public
The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public
Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery
Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery
HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery
HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery
Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses
Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
Research Interests
- Design, formulation and testing of novel drug carriers
- Improved understanding of tumour biology
- Application of external stimuli for improved drug delivery to tumours
- Transdermal delivery of drugs and vaccines
- Clinical trials of device + drug combinations
- Clinical and commercial translation of healthcare technologies
Research Groups
Research Team
Ms Matilde Maardalen - DPhil Student
Current Projects
OXCD3
Combining the best drug formulation and carrier systems with the best most targeted external stimuli.
Transdermavax
Use of formulation and external stimuli to drive vaccines and drugs into or across the skin.
Theroximmune
Combining external stimuli with immunotherapy for solid tumour treatment
Beyond Antibiotics
Addressing antimicrobial resistance
Most Recent Publications
The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public
The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public
Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery
Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery
HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery
HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery
Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses
Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
DPhil Opportunities
I am interested in supervising DPhil students working in vaccine formulation and delivery or solid tumour therapy.
Most Recent Publications
The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public
The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public
Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery
Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery
HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery
HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery
Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses
Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
